Does the presence or absence of oligoclonal bands in the cerebrospinal fluid alter the prognosis of MS? What about the number of bands? Is more oligoclonal bands worse? In this video, I review 6 publications on this exact topic and give my personal opinion.
Sources:
Oligoclonal Band Number as a Marker for Prognosis in Multiple Sclerosis: https://jamanetwork.com/journals/jamaneurology/fullarticle/780976
Oligoclonal Bands May Predict MS Relapses and Progression: https://www.mdedge.com/multiplesclerosishub/article/167052/multiple-sclerosis/oligoclonal-bands-may-predict-ms-relapses-and#:~:text=Data%20Suggest%20the%20Predictive%20Value%20of%20OCBs&text=More%20than%2090%25%20of%20patients,OCBs%20indicate%20a%20worse%20prognosis.
CSF oligoclonal band status informs prognosis in multiple sclerosis: a case control study of 100 patients: https://pubmed.ncbi.nlm.nih.gov/18829628/
Perrone’s poster: file:///C:/Users/13109/Downloads/CMSC%20Poster%202018%20-%20Chris%20Perrone.pdf
OCBs predicts conversion of CIS to MS: https://pubmed.ncbi.nlm.nih.gov/23431079/
Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study: https://www.nature.com/articles/s41598-021-94423-x
Review article on the topic from Portugal: https://biomedres.us/fulltexts/BJSTR.MS.ID.004611.php
Another study: https://europepmc.org/article/med/22909670
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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.
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